In-situ reaction monitoring for microwave assisted synthesis

Microwave Assisted Synthesis is rapidly becoming the method of choice in modern synthesis and discovery chemistry laboratories.

Microwave-assisted synthesis improves both throughput and turn-around time for chemists by offering the benefits of drastically reduced reaction times, increased yields, and purer products.

The ability to combine microwave technology with in-situ reaction monitoring as an analytical tools will offer opportunities for chemists to optimize the reaction conditions.

Enwave Optronics has created the EZRaman-MAS-InSitu models to help the optimization of reaction conditions, such as time and temperature for microwave enhanced synthesis.


Selected Publications by Enwave Customers:
  • Nicholas E Leadbeater, Jason R Schmink, 2008, Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions. Nature Protocols 3 , - 1 - 7 (2008)
  • Nicholas E Leadbeater , Jason R Schmink, Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions. Dalton Trans. 2008 Mar 14; (10):1341-5
  • Nicholas E Leadbeater , Rebecca J Smith, In situ Raman spectroscopy as a probe for the effect of power on microwave-promoted Suzuki coupling reactions Org Biomol Chem. 2007 Sep 7;5 (17):2770-4
  • Nicholas E Leadbeater , Rebecca J Smith , T Michael Barnard . Using in situ Raman monitoring as a tool for rapid optimisation and scale-up of microwave-promoted organic synthesis: esterification as an example. Org Biomol Chem. 2007 Mar 7;5 (5):822-5
  • Nicholas E Leadbeater , Rebecca J Smith, Real-time monitoring of microwave-promoted suzuki coupling reactions using in situ Raman spectroscopy. Org Lett. 8(20):4589-91.Org Lett. 2006 Sep 28;8 (20):4589-91
  • Barnard, T. M. and N. E. Leadbeater. 2006. Real-time monitoring of microwave-promoted organometallic ligand-substitution reactions using in situ Raman spectroscopy. Chem Commun (Camb). 2006 Sep 14; 34:3615-6.