In the dynamic world of pharmaceuticals and drug discovery, time is of the essence. The analytical tools one chooses may either speed along or hinder the process. Sensitive, efficient instrumentation is required. Raman spectroscopy is dersirable since it is able to measure samples down to 50cm-1 when compared to mid-IR systems only capable of reaching approximately 400cm-1. The feature is very attractive in the pharmaceutical industry because the spectra of most drug lattices are below 200 cm-1.

Raman spectroscopy is especially useful for lattice vibration studies for characterizing the solid state of a drug, as well as investigating polymorphism and amorphous systems. In addition, Raman spectroscopy is also useful in analysis and quantification of drug blends and in the examination of drug formulations and drug excipient incompatibilities.

Selected Publications by Enwave Customers:
  • "Raman Analysis of Low Concentration Ions in Water," Spectroscopy Magazine, Sept. 2009; 17.
  • Dudek, A. Surface properties in titanium with hydroxyapatite coating. Sept. 2009. Optica Applicata, 39 (4): 825-831.
  • Leadbeater, N.E. and Schmink, J.R. Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions. 2008. Nature Protocols 3 , - 1 - 7.
  • Leadbeater, N. E., Smith, R.J. and Barnard, T.M. Using in situ Raman monitoring as a tool for rapid optimisation and scale-up of microwave-promoted organic synthesis: esterification as an example. 2007. Org Biomol Chem. 5(5):822-5.